Fig. 4

Patient KE-02. The model output for tumor dynamics on an individual level under therapy compared with therapy-free simulations and data (left) as well as model output for the tumor size distribution at day 272 after primary tumor initiation, which is the patients primary diagnosis (right). Cf. Table 1 for the patients clinical parameters. For better readability, we have plotted the dynamics for the largest metastases only. The corresponding total mass depending on time including the non-plotted metastases is shown in Fig. 1