Fig. 7

Aβ concentrations depending upon activities of three autophagy steps. The surfaces specify time-averaged intracellular Aβ concentration 〈C_S3〉 (first row) and extracellular Aβ concentration 〈C_ES3〉 (second row) for basal parameter values; regions above and below the surfaces correspond to Aβ concentrations lower and higher than the basal values. The first and the second columns correspond to β/β⁽⁰⁾ = 10 and β/β⁽⁰⁾ = 100, respectively. Computations were performed with r_l3/r_l3⁽⁰⁾ and r_h3/r_h3⁽⁰⁾ varied in increments and the mixed cubic and quintic spline interpolation applied. On the surfaces in purple the Aβ concentrations display oscillations while oscillations are absent on the green surfaces