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Table 3 Parameter changes with altered protein intake and liver condition

From: Effects of a high protein diet and liver disease in an in silico model of human ammonia metabolism

Parameter Name

Protein in Diet (g per day)

Normal Enzyme Activity (mmoles/min)

Enzyme Activity in Liver Cirrhosis (mmoles/min)

Urea ex

71

0.244

0.244

100

0.343

0.343

122

0.417

0.417

NH3 ex

71

0.004

0.004

100

0.008

0.008

122

0.012

0.012

NH3 abs

71

0.492

0.492

100

0.693

0.693

122

0.845

0.845

Vmax CPS1

71

8.05

5.64

100

8.47

5.93

122

8.78

6.146

Vmax GLUL

No change with diet

12.3

2.46

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682