Fig. 8
Bi-molecular complex formation of sterol with phospholipids gives rise to non-linear dependence of ER sterol on sterol abundance in the PM. Sterol abundance in the ER was plotted as function of sterol abundance in the PM for low influx values (a) and for higher influx values (b). The equilibrium constant for sterol complexation in the outer PM leaflet, q4, was varied as indicated. All parameters were set as described in legend to Figs. 6 and 7, above. See text for further explanations