Fig. 4
A model of glucose turnover in the bloodstream. The tumor, by consuming glucose at an elevated rate, T g , may lead to increased de novo glucose production, D g (ie. muscle and fat catabolism), in fasting periods. This may be a large contributor to cachexia. As well, the Cori cycling rate, C g , a function of how much glucose is recycled in the liver from lactate generated from the body, leads to increased energy demand on the body when the tumor exports lactate due to its high rate of glycolysis. The liver glycogen buffer stores approximately 100-120Â g of glucose