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Table 7 Circuits of the Th network a

From: A method for the generation of standardized qualitative dynamical systems of regulatory networks

1

IFNγ→IFNγR→JAK1→STAT1¬IL4→IL4R→STAT6¬IL18R→IRAK→

2

IFNγ→IFNγR→JAK1→STAT1¬IL4→IL4R→STAT6¬IL12R→STAT4→

3

IFNγ→IFNγR→JAK1→STAT1¬IL4→IL4R→STAT6→GATA3→IL10→IL10R→STAT3¬

4

IFNγ→IFNγR→JAK1→STAT1¬IL4→IL4R→STAT6→GATA3¬STAT4→

5

IFNγ→IFNγR→JAK1→STAT1¬IL4→IL4R→STAT6→GATA3¬Tbet→

6

IFNγ→IFNγR→JAK1→STAT1→SOCS1¬IL4R→STAT6¬IL18R→IRAK→

7

IFNγ→IFNγR→JAK1→STAT1→SOCS1¬IL4R→STAT6¬IL12R→STAT4→

8

IFNγ→IFNγR→JAK1→STAT1→SOCS1¬IL4R→STAT6→GATA3→IL10→IL10R→STAT3¬

9

IFNγ→IFNγR→JAK1→STAT1→SOCS1¬IL4R→STAT6→GATA3¬STAT4→

10

IFNγ→IFNγR→JAK1→STAT1→SOCS1¬IL4R→STAT6→GATA3¬Tbet→

11

IFNγ→IFNγR→JAK1→STAT1→Tbet→

12

IFNγ→IFNγR→JAK1→STAT1→Tbet→SOCS1¬IL4R→STAT6¬IL18R→IRAK→

13

IFNγ→IFNγR→JAK1→STAT1→Tbet→SOCS1¬IL4R→STAT6¬IL12R→STAT4→

14

IFNγ→IFNγR→JAK1→STAT1→Tbet→SOCS1¬IL4R→STAT6→GATA3→IL10→IL10R→STAT3¬

15

IFNγ→IFNγR→JAK1→STAT1→Tbet→SOCS1¬IL4R→STAT6→GATA3¬STAT4→

16

IFNγ→IFNγR→JAK1→STAT1→Tbet¬GATA3→IL4→IL4R→STAT6¬IL18R→IRAK→

17

IFNγ→IFNγR→JAK1→STAT1→Tbet¬GATA3→IL4→IL4R→STAT6¬IL12R→STAT4→

18

IFNγ→IFNγR→JAK1→STAT1→Tbet¬GATA3→IL10→IL10R→STAT3¬

19

IFNγ→IFNγR→JAK1→STAT1→Tbet¬GATA3¬STAT4→

20

IL4→IL4R→STAT6→GATA3→

21

IL4R→STAT6→GATA3¬ Tbet→SOCS1¬

22

Tbet→

23

Tbet¬GATA3¬

24

GATA3→

25

IL4→IL4R→STAT6→GATA3¬Tbet→SOCS1¬JAK1→STAT1¬

26

JAK1→STAT1→SOCS1¬

27

JAK1→STAT1→Tbet→ SOCS1¬

  1. a. If the circuit has zero or an even number of negative interactions, it is considered positive; otherwise the circuit is negative. Circuits 1–24 are positive, and circuits 25–27 are negative.
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Theoretical Biology and Medical Modelling

ISSN: 1742-4682