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Figure 2 | Theoretical Biology and Medical Modelling

Figure 2

From: Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs

Figure 2

Predicted dose-response curves in case of skeletal muscle. The star symbol (*) represents the experimental data from Beavo et al. [35]. (A) Dose-response curves in the presence of inhibition of PP1 by inhibitor-1. The sensitivity of the fractional dose-response curve of glycogen synthase (curve a, Apparent Hill coefficient ~6.4), glycogen phosphorylase (curve b, ~33.8), phosphorylase kinase (curve c, ~7), inhibitor-1 (curve d, ~1.3), CAPK activation (curve e, ~1.12). (B) Dose-response curves in absence of inhibition of PP1 by inhibitor-1. The sensitivity fractional dose-response curve of Glycogen synthase (curve a, ~1.2); Glycogen phosphorylase (curve b, ~3.8); Phosphorylase kinase (curve c, ~0.8); Inhibitor-1 (curve d: ~1.3); CAPK activation (curve e, ~1.12).

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682