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Table 4 Rate equations and parameters of GSH synthesis and GSSG export that were used in the expanded model.

From: Dynamic simulation of red blood cell metabolism and its application to the analysis of a pathological condition

Rate equation for γ-glutamyl cysteine synthetase

Parameters for γ-glutamyl cysteine synthetase

Parameter

Value

Reference

Vmax

141.57 mM/h

31, 32

α

0.2

31

Kmglu

1.8 mM

31

Kmcys

0.1 mM

31

KiGSH

3.4 mM

31

KmATP

0.4 mM

31

Rate equation for glutathione synthetase

Parameters for glutathione synthetase

Parameter

Value

Reference

Km γ _GC

0.99 mM

33

KmGly

1,37 mM

33

KmATP

0,23 mM

33

α

2.6

33

Vmax

88.4 mM/h

33

Rate equation for GSSG export

Parameters for GSSG export

Parameter

Value

Reference

KmGSSG1

0.1 mM

34

KmATP

0.63 mM

34

Vm1

20 μ M/h

34