Figure 4

Simulation of G6PD deficiency using the expanded model. Changes in the concentrations of ATP (A), GO6P (B), GSH (C), GSSG (D), NADP (E) and NADPH (F) during RBC simulation. Broken lines are the results of the prototype model, while solid lines are the results of the expanded model during the same parameter shift as described in Figure 2. The simulation was run for 200,000 seconds (Approx. 55 h) in simulation time.