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Figure 1 | Theoretical Biology and Medical Modelling

Figure 1

From: Priming nonlinear searches for pathway identification

Figure 1

Test System. a) Gene network [42] used as test system for illustrating the proposed methods. Solid arrows represent material flow, while dashed arrows indicate regulatory signals that either activate (+) or inhibit (-) a process. The network contains two genes, Gene 1 and 2. X 1 is the mRNA produced from gene 1, X 2 is the enzyme for which the gene codes, and X 3 is an inducer protein catalyzed by X 2. X 4 is the mRNA produced from Gene 2 and X 5 is a regulator protein for which the gene codes. Positive feedback from X 3 and negative feedback from X 5 are assumed in the production of mRNAs from the two genes. b) S-system model of the gene network, according to Hlavacek and Savageau [42] and Kikuchi et al. [21].

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Theoretical Biology and Medical Modelling

ISSN: 1742-4682